S100β as an early biomarker of excitotoxic damage in spinal cord organotypic cultures
نویسندگان
چکیده
منابع مشابه
Axonal regeneration in hippocampal and spinal cord organotypic slice cultures
2. AIMSOFTHEPROJECT 32 2.1.
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The relationship between astrocytes, basal lamina and mesenchymal tissue was analyzed ultrastructurally in myelinated organotypic cultures of mouse spinal cord tissue grown in combination with its pia-arachnoid membrane. A discontinuous, well-developed basal lamina covered flat astrocytic processes which formed the basal layer of the explant opposing the pia-arachnoid membrane. Some astrocytic ...
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In co-cultures of embryonic rat spinal cord slices and skeletal muscle, spinal motoneurons innervate muscle fibres and drive muscle contractions. However, multi-electrode array (MEA) recordings show that muscle contractions often appear in the absence of population activity in the spinal cord networks. Such uncorrelated muscle activity persists when the population bursts in the neuronal network...
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Adult higher vertebrates have a limited potential to recover from spinal cord injury. Recently, evidence emerged that propriospinal connections are a promising target for intervention to improve functional regeneration. So far, no in vitro model exists that grants the possibility to examine functional recovery of propriospinal fibers. Therefore, a representative model that is based on two organ...
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BACKGROUND Minocycline, a second-generation tetracycline antibiotic, exhibits anti-inflammatory and neuroprotective effects in various experimental models of neurological diseases, such as stroke, Alzheimer's disease, amyotrophic lateral sclerosis and spinal cord injury. However, conflicting results have prompted a debate regarding the beneficial effects of minocycline. METHODS In this study,...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2014
ISSN: 0022-3042
DOI: 10.1111/jnc.12748